Vol.11 No.1


TOPICS

    1. Significance of Japanese Center for the Validation of Alternative Methods (JaCVAM) Establishment
    Yasuo Ohno
    Deputy Director-General
    National Institute of Health Sciences
    (pp. 1-3)

REVIEW

    2. Alternatives to Animal Experiments: Serving in the Middle Ground
    Michael Balls
    FRAME
    (pp. 4-14)

    3. Making Validated Alternatives Available -the Strategies and Work of the European Centre for the Validation of Alternative Methods (ECVAM)

    Valerie Zuang and Thomas Hartung

    European Commission, JRC - Joint Research Centre
    Institute for Health and Consumer Protection
    ECVAM - European Centre for the Validation of Alternative Methods
    (pp. 15-26)

TOPICS

    4. TestSmart DNT - Creating a Humane and Efficient Approach to Developmental Neurotoxicity Testing
    Alan M Goldberg
    Johns Hopkins Center for Alternatives to Animal Testing (CAAT)
    Department of Environmental Health Sciences
    Bloomberg School of Public Health
    Johns Hopkins University
    (pp. 27-30)

REVIEW

    5. Considerations Regarding the Importance of In Vivo Data for the Development of an Alternative to Conventional Skin Irritation Testing
    Hajime Kojima
    Research Laboratories, Nippon Menard Cosmetic Co., Ltd.
    (pp. 31-38)

    6. Recent Trends of Alternative Methods to Phototoxicity Testing in Japan

    Yuko Okamoto
    Fundamental Research Laboratory, KOSÉ Corporation
    (pp. 39-48)

    7. How are Epidermal Langerhans Cells Activated in the Initiation Phase of Allergic Contact Dermatitis?

    Setsuya Aiba
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    (pp. 49-58)

ORIGINAL ARTICLE

    8. Development of a Toxicity Evaluation System for Gaseous Compounds Using Air-liquid Interface Culture of a Human Bronchial Epithelial Cell Line, Calu-3
    Yasuyuki Sakai1,2, Kengo Tomita2,3, Motoyuki Suzuki2,4, Yoshiro Ono5 and Akiyoshi Sakoda2
    1 Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 114-0033, Japan
    2 Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
    3 Current affiliation: Environmental Science Center, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 114-0033, Japan
    4 Current affiliation: United Nations University, 5-53-70 Jingu-mae, Shibuya-ku, Tokyo 150-8558, Japan
    5 Department of Environmental Engineering, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan
    (pp. 59-67)

    9. Experimental Study on a Novel Chemical Application Procedure for in Vitro Skin Corrosivity Testing Using the Vitrolife-SkinTM Human Skin Model

    Noriyuki Morikawa1, Katsuyasu Morota1, Masakazu Suzuki1, Hajime Kojima2, Satoru Nakata2 and Hiroaki Konishi2
    1 Division of Research & Development, GUNZE Ltd., 1 Ishiburo, Inokura-shinmachi, Ayabe, Kyoto 623-8512, Japan
    2 Research Laboratories, Nippon Menard Cosmetic Co., Ltd., 2-7 Torimicho, Nishi-ku, Nagoya 451-0071, Japan
    (pp. 68-78)

    10. Gene Expression Profiling of Embryonic Fibroblasts Derived from a Rat Model of Periodontal Disease

    Tadashige Nozaki, Mitsuko Shinohara, Kazuya Iwamoto, Tsutomu Ohta and Kiyoshi Ohura
    Department of Pharmacology, Osaka Dental University, 8-1, Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan
    (pp. 78-85)


Instructions to Authors
(pp. 86-88)