Vol.11 No.2


REVIEW

    1. Progress in Establishing In Vitro Alternatives to Animal Experiments - Ethical and Scientific Challenges
    Horst Spielmann
    ZEBET
    (National Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments)
    at the Federal Institute for Risk Assessment
    (BfR = Bundesinstitut fûr Risikobewertung), Berlin, Germany
    (pp. 89-100)

TOPICS

    2. Phosphorylated ATM Foci as a Biochemical Marker for DNA Double Strand Breaks
    Keiji Suzuki1, Seiji Kodama2 and Masami Watanabe3
    1 Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    2 Radiation Biology Laboratory, Radiation Research Center, Frontier Science Innovation Center, Organization for University-Industry-Government Cooperation, Osaka Prefecture University, 1-2 gakuen-machi, Sakai, 599-8570, Japan
    3 Laboratory of Radiation, Biology, Kyoto University Research Reactor Institute, Kumatori-cho Sennan-gun, Osaka 590-0494, Japan
    (pp. 101-104)

ORIGINAL ARTICLES

    3. Effect of Digoxin on Chick Embryos with Hyperthyroidism Induced by L-Thyroxin
    Yuji Yoshiyama1, Tomoko Misaki2 and Takashi Sugiyama2
    1 Division of Clinical Pharmacy, Kyoritsu University of Pharmacy, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
    2 Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan
    (pp. 105-111)

    4. Toxic Interactions between Miconazole and Disopyramide in Chick Embryos

    Yuji Yoshiyama and Motoko Kanke
    Division of Clinical Pharmacy, Kyoritsu University of Pharmacy, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
    (pp. 112-117)

    5. Establishment of Hypoxanthine Phosphoribosyl-transferase(HPRT)-locus Mutation Assay System in Mouse ES Cells

    Hirohisa Tsuda*, Kiyoshi Sasaki and Noriho Tanaka
    Hatano Research Institute, Food and Drug Safety Center, 729-5, Ochiai, Hadano, Kanagawa 257-8523, Japan
    *Present address: Intellectual Property Office (Honjo Liaison Office), Kumamoto University, 1-1-1, Honjo, Kumamoto City, Kumamoto 862-8556, Japan

    (pp. 118-128)

    6. A Simple Method for Estimation of the Effects of Environmental Chemicals on the Formation of Primordial Germ Cells (PGCs) Using Embryos and Larvae of Xenopus laevis

    Michiko Kamimura Sakamoto
    Laboratory of Anatomy and Physiology, Kyusyu Nutrition Welfare University, Shimoitozu 5-1-1, Kokurakita-ku, Kitakyushu, Fukuoka 803-8511, Japan
    (pp. 129-135)

    7. Development of a Modified Local Lymph Node Assay using ATP Measurement as an Endpoint

    Kunihiko Yamashita, Kenji Idehara, Norio Fukuda, Gaku Yamagishi and Naoki Kawada
    Daicel Chemical Industries, Ltd., 1239, Shinzaike, Aboshiku, Himeji, Hyogo 671-1283, Japan
    (pp. 136-144)


Instructions to Authors, other's
(pp. 145-148)