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The 25rd Annual Meeting


Period: December 7th-9th, 2012
Venue: Faculty of Pharmacy, Keio University
1-5-30 Shiba-kouen, Minato-ku, Tokyo 105-8512, Japan
Congress Presidents: Prof. Yuichi Sugiyama (RIKEN)
Contact Information: E-mail: info@25th-jsaae.com
Abstract Submission: August 1st-September 30th, 2009
Program in Englishs: Program 

Theme: Science of Alternative to Animal Experiments 〜Mechanism-based Prediction〜
Office: Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Yokohama Bio Industry Center 2F, 1-6 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
TEL: +81-45-506-1815  FAX: +81-45-506-1800
Contact:registration@25th-jsaae.com (Registration)
      info@25th-jsaae.com (Other)
URL: http://www.asas.or.jp/jsaae/e_index.html

Deadline for abstract submission: September 28th, 2012
Deadline for early-bird registration: October 31st, 2012

Participation Fees
Annual Meeting Banquet at Keio University
(December 7th-9th, 2012) (December 8th, 2012)
Early-bird On site Early-bird On site
JSAAE member JPY 7,000 JPY 10,000 JPY 7,000 JPY 8,000
Non-member JPY 12,000 JPY 15,000 JPY 7,000 JPY 8,000
Student JPY 2,000 JPY 3,000 JPY 2,000 JPY 3,000


[Distinguished Lectures] December 8th and 9th, 2012
DL1: Micro-managing pluripotent stem cells towards generation of hepatocytes to be applicable in toxicology
Takahiro Ochiya (National Cancer Center Research Institute)

DL2: Sensitization study by qualitative structure-toxicity relationships (QSTR) approaches
Kazuhiro Sato (School of Medicine, University of Fukui)


[Educational Lecture] December 8th, 2012
EL1: Suggestion on the peer-review system for the laboratory animal care and use program in universities of Japan - from the standpoint of the review receiver -
Takashi Agui (Graduate School of Veterinary Medicine, Hokkaido University)


[Symposium] December 8th and 9th, 2012
S1: Trend of safety evaluation methods for cosmetic ingredients
Organizers:
Shigenobu Hagino (Shiseido Research Center)
Yuko Okamoto (KOS Corporation)
1. Trend of safety evaluation methods for cosmetic ingredients - Comprehensive summary -
Shigenobu Hagino (Shiseido Research Center)
2. Trend of alternative primary skin irritation test for the evaluation of cosmetic ingredients
Hidenobu Okumura (Special committee of JSAAE for alternative primary skin irritation test)
3. Trend of alternative methods of eye irritation test for evaluating cosmetic ingredients
Momoko Sunouchi (JaCVAM NIHS Japan)
4. Trend of alternative methods of single dose toxicity test for evaluating cosmetic ingredients
Tomomi Atobe (Shiseido Research Center)
5. Collaborative project in JCIA for skin sensitization testing strategy with non-animal tests
Masaaki Miyazawa (Japan Cosmetic Industry Association, Working group for in vitro skin sensitization)
6. Approach of JCIA for Safety Assessment of cosmetic ingredients in silico
Amane Inoue (Japan Cosmetic Industry Association, In silico Working Group)

S2: Frontiers of in vitro evaluation methods for accelerating drug development
Organizers:
Emi Nakashima (Faculty of Pharmacy, Keio University)
Kazuya Maeda (Graduate School of Pharmaceutical Sciences, The University of Tokyo)
1. Utilization of human-derived tissue samples and gene expression systems for the quantitative prediction of pharmacokinetics in humans (overview)
Kazuya Maeda (Lab. of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
2. In vitro evaluation of transplacental drug transport mechanisms
Masatoshi Tomi (Faculty of Pharmacy, Keio University)
3. Establishment of in vitro P-glycoprotein inhibition assay and its application
Hiroshi Sugimoto (Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited)
4. Development of a human immortalized cell-based blood-brain barrier model: A potentially promising tool for CNS drug development
Tomomi Furihata (Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University)
5. Model analysis on PK/PD relationship of antibiotics: Theoretical exploration for the most predictive index of pharmacological action
Yoshiaki Kitamura (Kyorin Pharmaceutical Co., Ltd)

S3: How can we take advantage of the progresses of biosystems engineering for cell-based assay?
Organizers:
Yasuyuki Sakai (Institute of Industrial Science, University of Tokyo)
Motoharu Kakiki (Drug Metabolism and Pharmacokinetics Research, Eisai Co., Ltd.)
1. General purpose of the symposium and related considerations from engineering point of view: microfluidics, micropatterning, 3D cellular organization and mass transfer
Yasuyuki Sakai (Institute of Industrial Science, University of Tokyo)
2. Expectations for new cell-based assay technology from drug development site
Motoharu Kakiki (Drug Metabolism and Pharmacokinetics Research, Eisai Co., Ltd.)
3. Spheroid array and cell-based assay
Kohji Nakazawa (Department of Life and Environment Engineering, The University of Kitakyushu)
4. Microfluidic Device for Cell-Based Assay
Shinji Sugiura (Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology)
5. Body on-a-chip: Improving in vitro prediction of human response to drugs
M. L. Shuler (Cornell University)

S4: In silico prediction for transmucosal/transdermal permeations of drugs and cosmetic ingredients
Organizers:
Hiroaki Todo (Josai University)
Kohtaro Yuta (In Silico Data Ltd.)
1. Recent trends and possibility on the in silico prediction
Hiroaki Todo (Josai University)
2. Safety assessment of cosmetic ingredients using the predictive percutaneous absorption in silico
Hirokazu Kouzuki (Research Center, Shiseido Co., Ltd.)
3. In silico prediction of transdermal drug delivery
Kakuji Tojo (Kyushu Institute of Technology)

S5: First-in human clinical study for early understanding of pharmacokinetics and pharmacodynamics of new drug candidates
Organizers:
Shinji Yamashita (Setsunan University, College of Pharmacy)
Yasuhiro Nakai (Taisho Pharmaceutical Co., Ltd, Development Management)
1. An overview : Current situation and future prospects of exploratory IND studies in Japan
Shinji Yamashita (Setsunan University, College of Pharmacy)
2. Prediction of pharmacokinetic properties and response of drugs based on microdose clinical study
Hiroyuki Kusuhara (The University of Tokyo, Graduate School of Pharmaceutical Sciences)
3. Nonclinical development for first-in-human studies under the current regulatory requirements
Eiichi Fuse (Kyowa Hakko Kirin, Co., Ltd, Non-Clinical Development Department)
4. Use of PKPD modeling in optimizing exploratory clinical studies
Ryosei Leo Kawai (Daiichi Sankyo Co. Ltd. Translational Medicine & Clinical Pharmacology)

S6: A new culture system utilizing a collagen vitrigel membrane chamber useful for ADMET prediction studies
[Supporting Organization: National Institute of Agrobiological Sciences]
Organizers:
Toshiaki Takezawa (National Institute of Agrobiological Sciences)
Seiichi Ishida (National Institute of Health Sciences)
1. Outline of symposium: Advantages of collagen vitrigel and its leading-edge studies
Toshiaki Takezawa (National Institute of Agrobiological Sciences)
2. Development of a new eye irritation test method utilizing a collagen vitrigel membrane chamber
Hiroyuki Yamaguchi (National Institute of Agrobiological Sciences, Kanto Chemical Co., Inc.)
3. Development of a new skin sensitization test method utilizing a collagen vitrigel membrane chamber
Tadashi Uchino (National Institute of Health Sciences)
4. Development of a new hepatic metabolism model utilizing a collagen vitrigel membrane chamber
Ayumi Oshikata (National Institute of Agrobiological Sciences)


[Luncheon Seminars] December 8th and 9th, 2012
LS1
Hideki Taniguchi (Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University)
[Sponsor: SEKISUI MEDICAL Co., Ltd.]

LS2
Atsuo Kishimoto (Research Institute of Science for Safety and Sustainability (RISS), National Institute of Advanced Industrial Science and Technology (AIST))
[Sponsor: Research Institute of Science for Safety and Sustainability (RISS), National Institute of Advanced Industrial Science and Technology (AIST)]


[25th Anniversary Lectures] December 7th, 2012

[International Symposium] December 7th, 2012

[Mandom Award Presentations] December 9th, 2012

[Challenge Contest] December 9th, 2012

[Oral Presentations] December 8th and 9th, 2012

[Poster Presentations] December 8th and 9th, 2012

[Exhibition] December 8th and 9th, 2012


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