REQUIRED EFFORT TO EVOLVE TOXICITY TESTING USING IN VITRO METHODS

MASAMI WATANABE
Division of Radiation Biology, Department of Health Sciences, Faculty of Pharmaceutical Sciences, Nagasaki University, Nagasaki, 852, Japan

Opinion :AATEX 3(3):81-84

Abstract
The procedures used to conduct chemical safety evaluations have developed over the years and continue to evolve with our understanding of the science of toxicology. The main objective of toxicity testing is to generate a toxicological database which can be utilized in human safety evaluation. Historically, the database to be utilized in the safety evaluation process was developed using whole-animal testing, human epidemiological studies and, in some cases, accidental human exposure data. However, as a result of recent biotechnological advances in the areas of cell culture and bioanalytical methodologies, new possibilities for in vitro studies and their applications to toxicity testing have been created. In light of these developments, the traditional approach to toxicity testing should be reevaluated.


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