1. Effects of Light Sources on the Prediction of Phototoxicity by the Yeast Growth Inhibition Phototoxicity Assay and the Red Blood Cell Photohemolysis Assay

   Masaaki Mori, Masatoshi Hoya, Mariko Sugiyama and Hiroshi Itagaki
   Safety & Analytical Research Center, Shiseido Co., Ltd., 2-12-1 Fukuura, Kanazawa-ku, Yokohama-ski, Kanagawa 236-8643, Japan
   (pp. 1-17)
   

2. Toxic Interactions between Amitriptyline and Disopyramide in Chick Embryos

   Yuji Yoshiyama¹, Takashi Sugiyama², and Motoko Kanke^{1
   1}Division of Clinical Pharmacy, Kyoritsu University of Pharmacy, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
   ²Division ofPathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan
   (pp. 18-23)
   

Review Article

1. Drug Discovery Today: The Value of Experiments on Human Tissues

   Robert A Coleman
   Pharmagene Laboratories Ltd., 2 Orchard Road, Royston, Hertfordshire, SG8 5HD, UK
   (pp. 24-35)

Outlook

1. European Good Practice Guide to the Administration of Substances and Removal of Blood
   - From the Aspect of Animal Welfare -

   Nobuko Nakai
   Department of Toxicology, Developmental Research Laboratory, Nippon Shinyaku Co., Ltd., 14 Nishinosho-Monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan
   (pp. 36-49, in Japanese)