Vol.11 No.1
TOPICS
1.
Significance of Japanese Center for the Validation of Alternative Methods (JaCVAM) Establishment
-
Yasuo Ohno
Deputy Director-General
National Institute of Health Sciences
(pp. 1-3)
REVIEW
2.
Alternatives to Animal Experiments: Serving in the Middle Ground
-
Michael Balls
FRAME
(pp. 4-14)
3.
Making Validated Alternatives Available -the Strategies and Work of the European Centre for the Validation of Alternative Methods (ECVAM)
-
Valerie Zuang and Thomas Hartung
European Commission, JRC - Joint Research Centre
Institute for Health and Consumer Protection
ECVAM - European Centre for the Validation of Alternative Methods
(pp. 15-26)
TOPICS
4.
TestSmart DNT - Creating a Humane and Efficient Approach to Developmental Neurotoxicity Testing
-
Alan M Goldberg
Johns Hopkins Center for Alternatives to Animal Testing (CAAT)
Department of Environmental Health Sciences
Bloomberg School of Public Health
Johns Hopkins University
(pp. 27-30)
REVIEW
5.
Considerations Regarding the Importance of In Vivo Data for the Development of an Alternative to Conventional Skin Irritation Testing
-
Hajime Kojima
Research Laboratories, Nippon Menard Cosmetic Co., Ltd.
(pp. 31-38)
6.
Recent Trends of Alternative Methods to Phototoxicity Testing in Japan
-
Yuko Okamoto
Fundamental Research Laboratory, KOSÉ Corporation
(pp. 39-48)
7.
How are Epidermal Langerhans Cells Activated in the Initiation Phase of Allergic Contact Dermatitis?
-
Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
(pp. 49-58)
ORIGINAL ARTICLE
8.
Development of a Toxicity Evaluation System for Gaseous Compounds Using Air-liquid Interface Culture of a Human Bronchial Epithelial Cell Line, Calu-3
-
Yasuyuki Sakai1,2, Kengo Tomita2,3, Motoyuki Suzuki2,4, Yoshiro Ono5 and Akiyoshi Sakoda2
1 Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 114-0033, Japan
2 Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan
3 Current affiliation: Environmental Science Center, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 114-0033, Japan
4 Current affiliation: United Nations University, 5-53-70 Jingu-mae, Shibuya-ku, Tokyo 150-8558, Japan
5 Department of Environmental Engineering, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan
(pp. 59-67)
9.
Experimental Study on a Novel Chemical Application Procedure for in Vitro Skin Corrosivity Testing Using the Vitrolife-SkinTM Human Skin Model
-
Noriyuki Morikawa1, Katsuyasu Morota1, Masakazu Suzuki1, Hajime Kojima2, Satoru Nakata2 and Hiroaki Konishi2
1 Division of Research & Development, GUNZE Ltd., 1 Ishiburo, Inokura-shinmachi, Ayabe, Kyoto 623-8512, Japan
2 Research Laboratories, Nippon Menard Cosmetic Co., Ltd., 2-7 Torimicho, Nishi-ku, Nagoya 451-0071, Japan
(pp. 68-78)
10.
Gene Expression Profiling of Embryonic Fibroblasts Derived from a Rat Model of Periodontal Disease
-
Tadashige Nozaki, Mitsuko Shinohara, Kazuya Iwamoto, Tsutomu Ohta and Kiyoshi Ohura
Department of Pharmacology, Osaka Dental University, 8-1, Kuzuhahanazono-cho, Hirakata, Osaka 573-1121, Japan
(pp. 78-85)
Instructions to Authors
(pp. 86-88)
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