Vol.2 No.1


Regular articles

  1. CYTOTOXICITY TEST OF ETHANOL USING VARIOUS HUMAN HEPATOMA AND OTHER CELL LINES
    Y. GU1, M. MIYAZAKI1, T. OHNO2, AND M. NAMBA1,3
    1Department of Cell Biology, Institute of Molecular and Cellular Biology, Okayama University Medical School, 2-5-1 Shikata, Okayama 700, Japan; 2Riken Cell Bank, Koyadai, Tsukaba Science City, Japan
    (pp. 1-5)

  2. DEVELOPMENT OF AN IN VITRO COMBINED ASSAY METHOD, EVALUATING HEMOGLOBIN DENATURATION AND HEMOLYTIC ACTIVITY IN RAT RED BLOOD CELLS, FOR THE PREDICTION OF EYE IRRITANCY POTENCIAL
    S. SUGAI1, K. MURATA1 AND M. WATANABE2
    1Research and Development Department, Kumiai Chemical Co. Ltd., 1-4-26, Ikenohata, Taito-ku, Tokyo 110, Japan; 2Faculty of Pharmaceutical Sciences, Nagasaki University 1-14, Bunkyo-machi, Nagasaki 852, Japan
    (pp. 7-18)

  3. A NEW APPROACH FOR THE DETECTION OF A CARCINOGENIC PROMOTER: ENZYME IMMUNOASSAY FOR ORNITHINE DECARBOXYLASE IN CULTURED NORMAL HUMAN SKIN CELLS
    T. FUJII1, C. TADA1, M. YAMAJI1, S. SAKO1, T. MATSUBARA1, M. IWAMI1, T, TAKAGI1, M. YAKIYAMA1, T. OKA2, and K. MIYAMOTO2
    1Laboratory of Biological Science, Teikoku Seiyaku Co., Sanbonmatsu, Kagawa and 2Department of Nutrition, School of Medicine, University of Tokushima, Kuramoto-Cho, Tokushima, Japan
    (pp. 19-24)

  4. QUANTITATIVE EVALUATION FOR THE PREDICTION OF EYE IRRITATION USING HEMOGLOBIN
    T. HAYASHI1, H. ITAGAKI2, T. FUKUDA1, U. TAMURA1 and S. KATO2
    1Shiseido Product Research Center, 2Shiseido Safety and Analytical Research Center, 1050 Nippa-cho, Kohoku-ku, Yokohama 723, Japan
    (pp. 25-31)

  5. LONG-TERM CYTOTOXICITY TESTING OF THE MEIC CHEMICALS 21-50 BY THE DETERMINATION OF THE PROTEIN CONTENT IN HUMAN EMBRYONIC LUNG CELLS
    PAUL J. DIERICKX1 AND BJORN EKWALL2
    1lnstituut voor Hygiene en Epidemiologie, Afdeling Toxikologie, Wytsmanstraat 14, B-1050 Brussel, Belgium; 2Department of Toxicology, University of Uppsala, Biomedical Centre, Box S44, S-S71 24 Uppsala, Sweden
    (pp. 33-36)

  6. INVITOX -- PROMOTING IN VITRO METHODS FOR TOXICITY TESTING
    K. UNGAR
    Fund for the Replacement of Animals in Medical Experiments (FRAME), 34 Stoney St., Nottingham, NG1 1NB, UK
    (pp. 37-43)

  7. The validation and acceptance of in vitro methods for toxicity testing.

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