Vol.3 No.1

Regular articles

  1. DEVELOPMENTAL TOXICITY OF BUTYLATED HYDROXYTOLUENE USING RAT AND HUMAN EMBRYONIC CELL ASSAYS
    T. TSUCHIYA1, N. MIYATA2, S. KAMIYA2, Y. IKARASHI1, A. NAKAMURA1 and A. TAKAHASHI3
    1Division of Medical Devices, 2Division of Orgunic Chemistry and 3Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences, Tokyo, Japan
    (pp. 1-8)
  2. VALIDATION OF POSTIMPLANTATION RODENT WHOLE EMBRYO CULTURE FOR IN VITRO TERATOGENICITY TESTING
    KIYOHITO NAKASHIMA
    Department of Chemistry Asahi University School of Dentistry, 1851-1 Hozumi, Hozumi-cho, Motosu-gun, Gifu 501-02, Japan
    (pp. 9-16)
  3. CARDIOVASCULAR MALFORMATIONS INDUCED BY CAFFEINE AND PHENOBARBITAL IN CHICK EMBRYOS
    TAKASHI KOBAYASHI, ATSUYUKI NISHIDA, AKANE KUROKAWA, and FUMIO ARIYUKI
    Safety Research Laboratory, Tanabe Seiyaku Co., Ltd., 3-16-89 Kashima, Yodogawa-ku, Osaka 532, Japan

    (pp. 17-27)
  4. NEUTRAL RED ASSAY USING NORMAL RABBIT CORNEAL EPITHELIAL CELLS GROWN IN SERUM-FREE MEDIUM AS AN ALTERNATIVE TO THE DRAIZE IRRITATION TEST
    HISASHI TORISHIMA1, RYOHEI YAMAMOTO1 and MASAMI WATANABE2
    1Biochemical Department, Technical Research Laboratory, Kurabo Industries Ltd., 14-5 Shimokida, Neyagwa, Osaka 572, Japan; 2School of Pharmaceutical Science, Nagasaki University, 1-14 Bunkyo-Machi, Nagasaki 852, Japan
    (pp. 29-36)

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