Vol.6 No.1


Original paper

  1. Alternative to primary Draize skin irritation test using cultured human skin model: Comparison of six endpoints

    Katsuyasu Morota1, Noriyuki Morikawa1, Shin-Ichiro Morita1 Hajime Kojima2, and Hiroaki Konishi2
    1Kyoto Research Laboratory, GUNZE Ltd., 1 Ishiburo, Inokura-shinmachi, Ayabe*city, Kyoto 623-0051, Japan
    2Research Institute, Nippon Menard Cosmetic Co., Ltd., 2-7 Torimicho, Nishi-ku, Nagoya 451-0071, Japan
    (pp. 41-51)
  2. The LD50 Values of Cardiovascular Drugs at Different Developmental Stages in Chick Embryos

    Hiroyuki Miyazaki, Takashi Sugiyama and Hideyo Shimada
    Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University,9-1,Shirokane 5-chome,Minato-ku,Tokyo 108-8641 Japan
    (pp. 52 - 57)
  3. Effects of Ca Channel Blockers under Different Lighting Conditions in the Chick-embryonic Heart

    Hiroyuki Miyazaki, Takashi Sugiyama and Hideyo Shimada
    Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University,9-1,Shirokane 5-chome,Minato-ku,Tokyo 108-8641 Japan
    (pp. 58 - 64)
  4. Cause of low embryogenesis-promoting ability of bovine and swine sera for 9.5-day rat embryo in culture

    Miyuki Katoh, Reiko Kimura and Ryujiro Shoji
    Department of Embryology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan.
    (pp. 65 - 71)
  5. Utilization of Chick Embryonic Electrocardio-grams to Detect the Proarrhythmic Actions by Antiarrhythmic Drugs

    Takashi Sugiyama, Hiroyuki Miyazaki and Hideyo Shimada
    Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University,@9-1, Shirokane 5-chome, Minato-ku, Tokyo 108-8641, Japan
    (pp. 72 - 78)

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