Vol.7 No. 1


Original paper

  1. Quantitative Prediction of ln Vivo Drug-drug Interactions from ln Vitro Data: Effects of Active Transport of Inhibitors into the Liver

    Shin-ichi Kanamitsu1, Yutaka Shinozaki2, Kiyomi Ito3, Takafumi Iwatsubo4, Hiroshi Suzuki and Yuichi Sugiyama

    Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
    1Current address: Section of Drug Metabolism Research, Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.
    2Current address: Central Research Laboratories, Zeria Phannaceutical Co., Ltd.
    3Current address: School of Pharmaceutical Sciences, Kitasato University
    4Current address: Drug Metabolism Laboratories, Institute for Drug Development Research, Yamanouchi Pharmaceutical Co., Ltd.
    (pp. 23 -29)
  2. Low-molecular Peptide Model of Protein Denaturation by UVA Irradiation and the Effect of Antioxidants

    Takao Ashikaga1,3, Akira Motoyama2, Hideyuki Ichikawa1, Hiroshi Itagaki 3 and Yoshihisa Sato1
    1Institute For Advanced Skin Research Inc.,
    2Shiseido Pharmaceutical Research Center,
    3Shiseido Life science Research Center, Yokohama, Japan
    (pp. 30 - 36)
  3. S-Conjugate-dependent Toxicity: Alternatives to Animal Studies

    M. W. Anders
    Department of Pharmacology and Physiology, University of Rochester Medical Center,
    601 Elmwood Avenue, Box 711, Rochester, New York 14642, U.S.A.
    (pp. 37 - 46)

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