Vol.7 No. 1
Quantitative Prediction of ln Vivo Drug-drug Interactions from ln Vitro Data:
Effects of Active Transport of Inhibitors into the Liver
Shin-ichi Kanamitsu1, Yutaka Shinozaki2, Kiyomi Ito3, Takafumi Iwatsubo4, Hiroshi Suzuki and Yuichi Sugiyama
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1,
Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
1Current address: Section of Drug Metabolism Research, Naruto Research Institute,
Otsuka Pharmaceutical Factory, Inc.
2Current address: Central Research Laboratories, Zeria Phannaceutical Co., Ltd.
3Current address: School of Pharmaceutical Sciences, Kitasato University
4Current address: Drug Metabolism Laboratories, Institute for Drug Development Research, Yamanouchi Pharmaceutical Co., Ltd.
(pp. 23 -29)
Low-molecular Peptide Model of Protein Denaturation by UVA Irradiation and the Effect of Antioxidants
Takao Ashikaga1,3, Akira Motoyama2, Hideyuki Ichikawa1, Hiroshi Itagaki 3 and Yoshihisa Sato1
1Institute For Advanced Skin Research Inc.,
2Shiseido Pharmaceutical Research Center,
3Shiseido Life science Research Center, Yokohama, Japan
(pp. 30 - 36)
S-Conjugate-dependent Toxicity: Alternatives to Animal Studies
M. W. Anders
Department of Pharmacology and Physiology, University of Rochester Medical Center,
601 Elmwood Avenue, Box 711, Rochester, New York 14642, U.S.A.
(pp. 37 - 46)