Vol.8 No.1
Original paper
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Utility of the Three-dimensional Cultured Human Skin Model as a Tool to Evaluate Skin Permeation of Drugs
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Tetsuya Watanabe1, Tetsuya Hasegawa1, Hidekazu Takahashi2, Takuya Ishibashi22, Kozo Takayama3 and Kenji Sugibayashi1
1 Josai University, 2 Toyobo Co., Ltd., 3 Hoshi University
(pp. 1 - 14)
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Effect of Penetration Enhancers on the Permeation of Drugs across a Three-Dimensional Cultured Human Skin Model: Comparison with the Effects Using Excised Hairless Rat Skin
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Tetsuya Watanabe1, Tetsuya Hasegawa1, Hidekazu Takahashi2, Takuya Ishibashi2 and Kenji Sugibayashi1
1 Josai University, 2 Toyobo Co., Ltd.
(pp. 15 - 22)
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The Utility of Whole Embryo Culture for Assessment on Embryotoxicity of Estrogenic Compounds in Rats
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Makiko Kuwagata1, Chiaki Watanabe1, Makio Takeda2, Hiroaki Aoyama2, Toshiaki Watanabe3 and Hiroshi Ono1
1 Food and Drug Safety Center, 2 Institute of Environmental Toxicology, 3 Yamagata University School of Medicine
(pp. 23 - 30)
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In Vitro Embryotoxicity Testing of Polymeric Substances for Dental Use by Differentiation of Embryonic Stem Cells
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Koichi Imai1, Horst Spielmann2, Gabi Scholz2, Ingeborg pohl2 and Masaaki Nakamura1
1 Osaka Dental University, 2 ZEBET (National German Center for the Documentation and Evaluation of Alternatives to Testing in Animals) at BgVV (National Center for Health Protection of Consumers and Veterinary Medicine )
(pp. 31 - 39)
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