DEVELOPMENT OF AN IN VITRO CELL TRANSFORMATION MODEL IN SYRIAN HAMSTER EMBRYO CELLS FOR CARCINOGEN DETECTION AND MECHANISTIC STUDIES

R.A. LEBOEUF, G.A. KERCKAERT, M.J. AARDEMA AND D.P. GIBSON
The Procter & Gamble Company, Miami Valley Laboratories

AATEX 1(2):60-64

Abstract
Results from studies demonstrating enhanced multi-stage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70 compared to ceils cultured in medium of higher pH are reviewed. These results are discussed in the context of the development of an in vitro cell transformation model for assessing the carcinogenic potential of chemicals.


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