AN ASSAY SYSTEM FOR DEVELOPMENTAL TOXICITY USING EMBRYOS AND LARVAE OF EXNOPUS LAEVIS MICHIKO K. SAKAMOTO, SHIN MIMA AND TAKASHI TANIMURA

MICHIKO SAKAMOTO, SHIN MIMA and TAKASHI TANIMURA
Department of Anatomy, Kinki University School of Medicine, Osakasayama City, Osaka 589, Japan

AATEX 1(3):172-177

Abstract
Xenopus larvis embryos and larvae were exposed to seventeen chemicals for the evaluation of Xenopus laevis embryo and larva system as one of alternatives of devclopmental toxicity of chemicals. All of the chemicals induced some developmental toxicity in a dose-dependent manner. Based on our data and those of other investigators, it is considered that Xenopus embryo and larva system is a good candidate for a simple and effective test system to evaluate developmental toxicants. Furthermore, advantages and disadvantages of this system are discussed.


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