Review article :AATEX 10(1):36-49 (in Japanese)
Administration of test substances and removal of blood samples are the most common and basic procedures performed in animal experiments. To refine animal experiments to cause the minimum amount of stress and to avoid duplication of animal work, data sharing among laboratories is important. EFPIA (the European Federation of Pharmaceutical Industries Associations) and ECVAM (the European Center for the Validation of Alternative Methods) published A Good Practice Guide to the Administration of Substances and Removal of Blood. This guide provides researchers with an up-to-date and easy-to-use set of data sheets to aid in the process of study design, as well as afford maximum welfare considerations to the experimental animals. I hope that this guide will also provide background data useful to those responsible for protocol designs and reviews in Japan.
Key words: Europe, good practice guide, administration, removal of blood, animal experiments